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- Title
Macromolecular contrast media. A new approach for characterising breast tumors with MR-mammography.
- Authors
Daldrup, H. E.; Roberts, T. P. L.; Mühler, A.; Gossmann, A.; Roberts, H. C.; Wendland, M.; Rosenau, W.; Brasch, R. C.
- Abstract
The value of macromolecular contrast agents (MMCM) for the characterization of benign and malignant breast tumors will be demonstrated in this review. Animal studies suggest a high potential of MMCM to increase the specificity of MR-mammography. The concept of tumor differentiation is based on the pathological hyperpermeability of microvessels in malignant tumors. MMCM show a leak into the interstitium of carcinomas, whereas they are confined to the intravascular space in benign tumors. Capabilities and limitations of the MMCM-prototype. Albumin-Gd-DTPA, for breast tumor characterization will be summarized and compared to the standard low molecular weight contrast agent Gd-DTPA. Initial experience with new MMCM, such as Dendrimers, Gd-DTPA-Polylysine and MS-325 will be outlined. The potential of “blood-pool“-iron oxides, such as AMI-227 for the evaluation of tumor microvascular permeabilities will be discussed.
- Publication
Der Radiologe, 1997, Vol 37, Issue 9, p733
- ISSN
0033-832X
- Publication type
Article
- DOI
10.1007/s001170050275