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- Title
An Efficient Stereoselective Total Synthesis of Bioactive (3 R,5 R)-1-(4-Hydroxyphenyl)-7-phenylheptane-3,5-diol via Asymmetric Aldol Reaction.
- Authors
Ramesh, Perla; Raju, Atla; Fadnavis, Nitin W.
- Abstract
An efficient stereoselective total synthesis of (3 R,5 R)-1-(4-hydroxyphenyl)-7-phenylheptane-3,5-diol ( 1) is reported based on the Mukaiyama aldol reaction. The total synthesis of compound 1 was accomplished with 30% overall yield in simple eight steps from commercially available trans-cinnamaldehyde.
- Subjects
STEREOSELECTIVE reactions; STEREOCHEMISTRY; STEREOISOMERS; STERIC hindrance; CHEMICAL synthesis; CHEMICAL bonds; CHEMICAL structure
- Publication
Helvetica Chimica Acta, 2016, Vol 99, Issue 1, p70
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201500189