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- Title
C-11-Methionin-PET/CT zur Lokalisation von Nebenschilddrüsenadenomen.
- Authors
Weber, T.; Luster, M.
- Abstract
Background and objectives: In primary hyperparathyroidism (pHPT) preoperative localization of parathyroid adenomas enables focussed unilateral parathyroidectomy. Ultrasound and sestamibi scintigraphy are the recommended standard procedures for primary diagnostics of pHPT and C-11 methionine positron emission tomography computed tomography (Met-PET/CT) is the latest technique for localization of hyperfunctioning parathyroid glands. Methods: This review presents the results of Met-PET/CT on the basis of a selective literature search using the keywords 'primary hyperparathyroidism and methionine', 'primary hyperparathyroidism and PET', 'parathyroid adenomas and methionine' and 'parathyroid adenomas and PET'. Results: Localization of single gland adenomas can be achieved with Met-PET/CT in 79-91 % of cases. The advantages of this procedure are a high sensitivity even in operations for recurrencies or concomitant thyroid nodules and an accurate detection even with atypical localizations. In multiglandular disease a localization of more than one hyperfunctioning gland remains difficult. Potential limitations of the method include the restricted availability and the relatively high costs of Met-PET/CT. Conclusions: Using Met-PET/CT hyperfunctioning parathyroid glands can be exactly localized in most patients with pHPT. Indications for this procedure are mostly when preoperative standard tests are negative and in parathyroid surgery for recurrencies.
- Subjects
HYPERPARATHYROIDISM treatment; PARATHYROIDECTOMY; ADENOMA; POSITRON emission tomography; METHIONINE; PARATHYROID gland surgery; THERAPEUTICS
- Publication
Der Chirurg, 2014, Vol 85, Issue 7, p601
- ISSN
0009-4722
- Publication type
Article
- DOI
10.1007/s00104-013-2695-5