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- Title
Ablation rate after radioactive iodine therapy in patients with differentiated thyroid cancer at intermediate or high risk of recurrence: a systematic review and a meta-analysis.
- Authors
Klain, Michele; Nappi, Carmela; Zampella, Emilia; Cantoni, Valeria; Green, Roberta; Piscopo, Leandra; Volpe, Fabio; Manganelli, Mariarosaria; Caiazzo, Elisa; Petretta, Mario; Schlumberger, Martin; Cuocolo, Alberto
- Abstract
Purpose: We performed a systematic review and a meta-analysis to investigate the successful ablation rate after radioiodine (RAI) administration in patients with differentiated thyroid cancer (DTC) at intermediate-high risk of recurrence. Methods: A comprehensive literature search of the PubMed, Scopus, and Web of Science databases was conducted according to the PRISMA statement. Results: The final analysis included 9 studies accounting for 3103 patients at intermediate-high risk of recurrence. In these patients, the successful ablation rates ranged from 51 to 94% with a 71% pooled successful ablation and were higher in intermediate (72%) than in high (52%)-risk patients. Despite the rigorous inclusion standards, a significant heterogeneity among the evaluated studies was observed. Higher administered RAI activities are associated with a lower successful ablation rate in the whole population and in the subgroup of high-risk patients. Furthermore, pooled recurrence rate in intermediate-risk patients achieving successful ablation was only 2% during the subsequent 6.4-year follow-up while the pooled recurrence rate was 14% in patients who did not achieve a successful ablation. Conclusion: In a large sample of 3103 patients at intermediate-high risk of persistent/recurrent disease, 71% of patients achieved a successful ablation. In these intermediate-risk patients, the probability of subsequent recurrence is low and most recurrence occurred in those with already abnormal findings at the first control.
- Subjects
IODINE isotopes; THYROID cancer; SCIENCE databases; META-analysis; WEB databases
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2021, Vol 48, Issue 13, p4437
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-021-05440-x