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- Title
Initial investigation of F-NaF PET/CT for identification of vertebral sites amenable to surgical revision after spinal fusion surgery.
- Authors
Quon, Andrew; Dodd, Robert; Iagaru, Andrei; Abreu, Marcelo; Hennemann, Sergio; Neto, Jose; Sprinz, Clarice
- Abstract
Purpose: A pilot study was performed in patients with recurrent back pain after spinal fusion surgery to evaluate the ability of F-NaF PET/CT imaging to correctly identify those requiring surgical intervention and to locate a site amenable to surgical intervention. Methods: In this prospective study 22 patients with recurrent back pain after spinal surgery and with equivocal findings on physical examination and CT were enrolled for evaluation with F-NaF PET/CT. All PET/CT images were prospectively reviewed with the primary objective of identifying or ruling out the presence of lesions amenable to surgical intervention. The PET/CT results were then validated during surgical exploration or clinical follow-up of at least 15 months. Results: Abnormal F-NaF foci were found in 16 of the 22 patients, and surgical intervention was recommended. These foci were located at various sites: screws, cages, rods, fixation hardware, and bone grafts. In 6 of the 22 patients no foci requiring surgical intervention were found. Validation of the results by surgery (15 patients) or on clinical follow-up (7 patients) showed that F-NaF PET/CT correctly predicted the presence of an abnormality requiring surgical intervention in 15 of 16 patients and was falsely positive in 1 of 16. Conclusion: In this initial investigation, F-NaF PET/CT imaging showed potential utility for evaluation of recurrent symptoms after spinal fusion surgery by identifying those patients requiring surgical management.
- Subjects
SPINAL fusion; SPINAL surgery; BACKACHE; REOPERATION; PERIODIC health examinations; TOMOGRAPHY; PILOT projects; LONGITUDINAL method; PATIENTS
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2012, Vol 39, Issue 11, p1737
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-012-2196-7