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- Title
Study of the Pressing Process of N-Butyl-N-Methyl-1-Phenylpyrrolo-[1,2-a]Pyrazine-3-Carboxamide (GML-3) Tablets Using Mathematical Modeling Techniques.
- Authors
Markeev, V. B.; Tishkov, S. V.; Blynskaya, E. V.; Alekseev, K. V.
- Abstract
N-Butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide (GML-3) is an original molecule developed at the Research Zakusov Institute of Pharmacology. GML-3 has both anxiolytic and antidepressant activity, which makes the development of tablets based on it a promising task. Optimization of the pressing process is currently an urgent task of the pharmaceutical industry because this technological stage has a significant impact on the disintegration of tablets and the release of the active pharmaceutical ingredient. The Heckel and Kuenz–Leuenberger models were used to study the pressing process of GML-3 tablets. These models were compared to select the most reliable description of pressing GML-3 tablets from granules. Granules with polyvinylpyrrolidone (PVP) and hydroxypropylmethylcellulose (HPMC) as a binder were used.
- Subjects
MATHEMATICAL models; PHARMACEUTICAL industry; RESEARCH institutes
- Publication
Pharmaceutical Chemistry Journal, 2024, Vol 57, Issue 12, p1998
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-024-03107-z