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- Title
Cytotoxic Activity Against SH-SY5Y Neuroblastoma Cells of Heterocyclic Compounds Containing gem-Dichlorocyclopropane and/or 1,3-Dioxacycloalkane Fragments.
- Authors
Kuz'mina, U. Sh.; Raskil'dina, G. Z.; Ishmetova, D. V.; Sakhabutdinova, G. N.; Dzhumaev, Sh. Sh.; Borisova, Yu. G.; Vakhitova, Yu. V.; Zlotskii, S. S.
- Abstract
The cytotoxic properties of ethers, esters, and ketones containing gem-dichlorocyclopropane and/or 1,3-dioxacycloalkane fragments were studied in vitro using normal human embryonic kidney (HEK293) and human neuroblastoma cancer cell lines (SH-SY5Y). Compounds producing selective toxic effects on SH-SY5Y cells were identified and included 4,4-[1,2-diphenylene-bis(methylenoxymethylene)-bis(2,2-dimethyl-1,3-dioxolane) (IC50 = 33.21 ± 1.34 μM), [3-(butoxymethyl)-2,2-dichlorocyclopropyl]benzene (IC50 = 88.60 ± 6.93 μM), and 1,2-bis{[(2,2-dichlorocyclopropyl)methoxy]methyl}benzene (IC50 = 90.90 ± 5.78 μM). High selectivity indices (SI) were established for 4-({[(2-chloromethyl)benzyl]oxy}methyl)-2,2-dimethyl-1,3-dioxolane (SI = 8.03) and 4,4-[1,2-diphenylene-bis(methylenoxymethylene)]-bis(2,2-dimethyl-1,3-dioxolane) (SI = 3.01). The results allowed directions for the synthesis of new cytotoxic heterocyclic substances with gem-dichlorocyclopropane and/or 1,3-dioxacycloalkane fragments with specificity for SH-SY5Y cells to be determined.
- Subjects
HETEROCYCLIC compounds; NEUROBLASTOMA; CELL lines; POISONS; KETONES
- Publication
Pharmaceutical Chemistry Journal, 2022, Vol 55, Issue 12, p1293
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-022-02574-6