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- Title
PHOSPHOCALCIC METABOLISM IN AUTOIMMUNE THYROID DISEASES.
- Authors
Tanțoş, Teodora-Lidia; Milu, Claudia Emanuela; Paşcanu, Maria Ionela
- Abstract
Background: Autoimmune thyroid diseases are complex pathologies influenced by both genetic predisposition and environmental factors. Hashimoto's thyroiditis and Basedow-Graves disease may be seen as opposite ends of the autoimmune thyroid disease spectrum but, in reality, there is an overlap between the two. Thyroid hormones play an important role in phosphocalcic metabolism and have a direct effect on bone turnover. Objective: The study aims to evaluate phosphocalcic metabolism parameters in autoimmune thyroid disease patients and assess their correlation with thyroid function and antibodies. Material and methods: This study consists of a group of 196 patients with autoimmune thyroid diseases, who were referred to the Endocrinology Clinic of Mures County Hospital between January 2022 and April 2023. Autoimmune thyroid disease is evidenced by the presence of increased anti-thyroid peroxidase antibodies (TPOAb) and thyrotropin receptor antibodies (TRAb) levels. The patients were assessed for thyroid function, anti-thyroid antibodies and phosphocalcic metabolism parameters. Results: A total of 158 patients with Hashimoto's thyroiditis and 38 patients with Graves' disease were included. Statistical analysis of the studied parameters revealed significant differences between the two groups. Specifically, mean values of corrected calcium (p = 0.0120) and alkaline phosphatase (p < 0.001) were significantly higher in patients with Graves' disease. In both patient groups, vitamin D correlates linearly positive with FT4 (Hashimoto's: R = 0.2053, R2 = 0.0421, p = 0.0201; Graves': R = 0.4341, R2 = 0.1884, p = 0.0092). Further classification of patients based on age and menopausal status yielded additional insights. A negative correlation between corrected calcium levels and TPOAb levels was observed in postmenopausal females (ρ = -0.3794, p = 0.0353) and in patients aged over 65 (ρ = -0.6485, p = 0.0425). Conclusions: The results confirm the influence of thyroid hormones on phosphocalcic metabolism, highlighting its importance in managing autoimmune thyroid diseases.
- Subjects
ROMANIA; CALCIUM metabolism; THYROID gland physiology; PHOSPHATE metabolism; VITAMIN D metabolism; AUTOIMMUNE thyroiditis; AUTOANTIBODIES; DISEASE management; CONFERENCES &; conventions; THYROID hormones; BIOMARKERS
- Publication
Acta Marisiensis. Seria Medica, 2024, Vol 70, p26
- ISSN
2668-7755
- Publication type
Article