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- Title
Telangiectasia hemorrágica hereditaria durante el embarazo: Reporte de caso.
- Authors
Guzmán-López, Abel; Rubén Treviño-Montemayor, Óscar; Janet Trejo-Guzmán, Esthela; Antonio Soria-López, Juan; Ignacio Guzmán-Pérez, Tomás
- Abstract
BACKGROUND: Hereditary hemorrhagic telangiectasia, or Rendu-Osler-Weber syndrome, is an autosomal inherited vascular disease characterized by mucocutaneous telangiectasias and arteriovenous malformations in the lung, brain and liver. The estimated prevalence is 1.5 to 2 affected persons per 10,000 population. Ninety percent of cases are due to a mutation in the endoglin gene and in the activin receptor-like kinase 1 gene (ACVRL1). In pregnant women, hereditary hemorrhagic telangiectasia is high risk, especially during the second and third trimester. OBJECTIVE: To report a case of hereditary hemorrhagic telangiectasia and to expose the complications that can occur during pregnancy. CLINICAL CASE: 23-year-old patient, with hereditary family history of mother diagnosed with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome) who died at 38 years of age. Personal pathological history of hereditary hemorrhagic telangiectasia, diagnosed at the age of 12 years after multiple episodes of epistaxis. She was treated with multiple blood transfusions and 200 mg of ferrous sulfate every 24 hours. CONCLUSION: Hereditary hemorrhagic telangiectasia conditions, in pregnant women, the appearance of complications that can put the life of the mother and fetus at risk. Women with a known history should be evaluated before conception in order to know the status of the disease.
- Subjects
PREGNANT women; HEREDITARY hemorrhagic telangiectasia; ARTERIOVENOUS malformation; PREGNANCY complications; FETAL development; MATERNAL mortality; NOSEBLEED; ENDOGLIN
- Publication
Ginecología y Obstetricia de México, 2022, Vol 90, Issue 7, p623
- ISSN
0300-9041
- Publication type
Article
- DOI
10.24245/gom.v90i7.7254