We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Histoplasma capsulatum Infection with Extensive Lytic Bone Lesions Mimicking LCH.
- Authors
Mathews, Divya Mariam; John, Rikki; Verghese, Valsan; Parmar, Harshad; Chaudhary, Narendra; Mishra, Sataroopa; Mathew, Leni
- Abstract
Multiple lytic bone lesions in a child can be a manifestation of various diseases like Langerhans cell histiocytosis, metastatic neuroblastoma, leukemia, hyperparathyroidism, multifocal osteomyelitis and histoplasmosis. Disseminated histoplasmosis caused by Histoplasma capsulatum var. duboisii is well known to present with multiple osteolytic lesions in immunocompromised adults and is mostly restricted to the African subcontinent. Histoplasmosis seen in American and Asian countries is caused by Histoplasma capsulatum var. capsulatum, which presents with pulmonary and systemic manifestations and rarely bone involvement. We report a case of histoplasmosis, caused by H. capsulatum var. capsulatum with extensive lytic bone lesions in a 13 year old immunocompetent boy who presented with prolonged fever, weight loss and multiple boggy swellings. He responded to amphotericin and is currently on Itraconazole. This case is unique for extensive osteolytic lesions with H. capsulatum var. capsulatum infection in an immunocompetent child.
- Subjects
HISTOPLASMA capsulatum; BONE diseases in children; LANGERHANS-cell histiocytosis; NEUROBLASTOMA; HYPERPARATHYROIDISM; LEUKEMIA; AMPHOTERICIN B; ANTIFUNGAL agents; HISTOPLASMOSIS diagnosis; FUNGI classification; ITRACONAZOLE; FEVER; FUNGI; HISTOPLASMOSIS; IMMUNE response; IMMUNOCOMPETENT cells; TREATMENT effectiveness; THERAPEUTICS
- Publication
Journal of Tropical Pediatrics, 2016, Vol 62, Issue 6, p496
- ISSN
0142-6338
- Publication type
journal article
- DOI
10.1093/tropej/fmw040