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- Title
MSCs and CAFs interactions in the prostate and bladder cancer microenvironment as the potential cause of tumour progression .
- Authors
Balik, Karolina; Kaźmierski, Łukasz; Maj, Małgorzata; Bajek, Anna
- Abstract
The tumour microenvironment (TME) is the broadly understood environment around the tumour. Cancer-associated fibroblasts (CAFs), Mesenchymal Stromal Cells (MSCs), and molecules synthesized by them are part of it. Both CAFs and MSCs can promote tumour progression by induction of an immunosuppressive, pro-inflammatory environment. Through indirect and direct cell-to-cell interactions they also have a pro-proliferative, pro-angiogenic, and pro-invasive effect on cancer cells. They can lead to aggressive cancer formation. At this stage, it is important to conduct research to modulate TME towards inhibition of cancer progression and preventing resistance to already introduced drugs. Moreover, it is extremely important to study these interactions in light of using MSCs in a drug-delivery strategy.
- Subjects
BLADDER tumors; DISEASE progression; FIBROBLASTS; CELL physiology; IMMUNOSUPPRESSION; CANCER; CELL communication; CANCER patients; CELL proliferation; TISSUE engineering; CELL lines; MESENCHYMAL stem cells; PROSTATE tumors
- Publication
Medical Research Journal (2451-2591), 2023, Vol 8, Issue 1, p76
- ISSN
2451-2591
- Publication type
Article
- DOI
10.5603/MRJ.a2023.0009