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- Title
Simultaneous Electrochemical Analysis of Uric Acid and Xanthine in Human Saliva and Serum Samples Using a 3D Reduced Graphene Oxide Nanocomposite-Modified Electrode.
- Authors
Han, Seong-Hyun; Moon, Ki Won; Lee, Yun Jong; Lee, Gi-Ja
- Abstract
Accurate and effective diagnosis and individualized management of gout can be potentially achieved by detecting uric acid (UA) and xanthine (XT) simultaneously using an easy-to-use method. Herein, we report simultaneous detection of UA and XT using a 3-dimensional (3D) macroporous gold nanoparticle-incorporated reduced graphene oxide–carbon nanotube nanocomposite (GNP/rGO-CNT). The GNP/rGO-CNT was simply prepared on a glassy carbon electrode (GCE) by one-step electrochemical deposition/co-reduction. It displayed highly sensitive and selective responses to UA and XT, showing excellent stability and good reproducibility in neutral pH. It was demonstrated that 3D GNP/rGO-CNT on GCE could detect UA and XT in human saliva and blood serum simultaneously. This GNP/rGO-CNT for simultaneous detection of UA and XT in human body fluids can be utilized for monitoring drug adherence for gout treatment, together with gout diagnosis.
- Subjects
GRAPHENE oxide; OXIDE electrodes; XANTHINE; ELECTROCHEMICAL analysis; URIC acid; CARBON electrodes; CARBON nanotubes
- Publication
Chemosensors, 2023, Vol 11, Issue 3, p185
- ISSN
2227-9040
- Publication type
Article
- DOI
10.3390/chemosensors11030185