We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development of Antiepileptic Drugs throughout History: From Serendipity to Artificial Intelligence.
- Authors
Corrales-Hernández, María Gabriela; Villarroel-Hagemann, Sebastián Kurt; Mendoza-Rodelo, Isabella Esther; Palacios-Sánchez, Leonardo; Gaviria-Carrillo, Mariana; Buitrago-Ricaurte, Natalia; Espinosa-Lugo, Santiago; Calderon-Ospina, Carlos-Alberto; Rodríguez-Quintana, Jesús Hernán
- Abstract
This article provides a comprehensive narrative review of the history of antiepileptic drugs (AEDs) and their development over time. Firstly, it explores the significant role of serendipity in the discovery of essential AEDs that continue to be used today, such as phenobarbital and valproic acid. Subsequently, it delves into the historical progression of crucial preclinical models employed in the development of novel AEDs, including the maximal electroshock stimulation test, pentylenetetrazol-induced test, kindling models, and other animal models. Moving forward, a concise overview of the clinical advancement of major AEDs is provided, highlighting the initial milestones and the subsequent refinement of this process in recent decades, in line with the emergence of evidence-based medicine and the implementation of increasingly rigorous controlled clinical trials. Lastly, the article explores the contributions of artificial intelligence, while also offering recommendations and discussing future perspectives for the development of new AEDs.
- Subjects
ANTICONVULSANTS; ARTIFICIAL intelligence; DRUG development; SERENDIPITY; VALPROIC acid
- Publication
Biomedicines, 2023, Vol 11, Issue 6, p1632
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11061632