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- Title
High density lipoprotein: the double-edge sword on endothelial function.
- Authors
ZHAO Lili; MAO Yongmin
- Abstract
Chronic exposure to risk factors at the beginning stage of atherosclerosis development can damage endothelium and ultimately initiate endothelial dysfunction. Endothelial dysfunction is one of the major mechanisms in atherosclerosis development. High-density lipoprotein (HDL) is a lipoprotein with complicated function and is composed of a variety of proteins and lipids. Epidemiological studies showed an inverse correlation between HDL and atherosclerosis. The protective role of HDL on endothelium might related to its function in reversing cholesterol transport, reducing peripheral cholesterol accumulation, preventing foam cells formation, dilating vessels, antioxidant and anti-inflammation, all of which antagonize development of atherosclerosis. But HDL obtained from patients with cardiovascular disease which has known dysfunctional HDL may induce endothelial dysfunction. This review addresses the relationships between functional HDL or dysfunctional HDL with the endothelial function.
- Subjects
ATHEROSCLEROSIS risk factors; ENDOTHELIUM diseases; HIGH density lipoproteins; CHOLESTEROL; PATHOLOGICAL physiology
- Publication
Tianjin Medical Journal, 2015, Vol 43, Issue 4, p439
- ISSN
0253-9896
- Publication type
Article
- DOI
10.11958/j.issn.0253-9896.2015.04.029