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- Title
Superior mitochondrial adaptations in human skeletal muscle after interval compared to continuous single-leg cycling matched for total work.
- Authors
MacInnis, Martin J.; Zacharewicz, Evelyn; Martin, Brian J.; Haikalis, Maria E.; Skelly, Lauren E.; Tarnopolsky, Mark A.; Murphy, Robyn M.; Gibala, Martin J.
- Abstract
Key points A classic unresolved issue in human integrative physiology involves the role of exercise intensity, duration and volume in regulating skeletal muscle adaptations to training., We employed counterweighted single-leg cycling as a unique within-subject model to investigate the role of exercise intensity in promoting training-induced increases in skeletal muscle mitochondrial content., Six sessions of high-intensity interval training performed over 2 weeks elicited greater increases in citrate synthase maximal activity and mitochondrial respiration compared to moderate-intensity continuous training matched for total work and session duration., These data suggest that exercise intensity, and/or the pattern of contraction, is an important determinant of exercise-induced skeletal muscle remodelling in humans., Abstract We employed counterweighted single-leg cycling as a unique model to investigate the role of exercise intensity in human skeletal muscle remodelling. Ten young active men performed unilateral graded-exercise tests to measure single-leg
- Subjects
EXERCISE intensity; EXERCISE physiology; SKELETAL muscle; PHYSIOLOGICAL aspects of cycling; MITOCHONDRIA
- Publication
Journal of Physiology, 2017, Vol 595, Issue 9, p2955
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP272570