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- Title
Synthesis of Substituted Aminopyrimidines as Novel Promising Tyrosine Kinase Inhibitors.
- Authors
Stolpovskaya, N. V.; Kruzhilin, A. A.; Zorina, A. V.; Shikhaliev, Kh. S.; Ledeneva, I. V.; Kosheleva, E. A.; Vandyshev, D. Yu.
- Abstract
A procedure has been proposed for the synthesis of a series of substituted N-(1,3-thiazol-2-yl)-pyrimidin-2-amines and N-(pyrimidin-2-yl)thioureas by reactions of diethyl 2-(ethoxymethylidene)malonate and ethyl 2-(ethyoxymethylidene)-3-oxobutanoate with 1,3-thiazol-2-ylguanidines and amidinothiourea, respectively. Preliminary screening has revealed high inhibitory activity of ethyl 2-(carbamothioylamino)-4-methylpyrimidine-5-carboxylate and ethyl 2-(carbamothioylamino)-6-oxo-1,6-dihydropyrimidine-5-carbox-ylate toward several protein kinases.
- Subjects
PROTEIN-tyrosine kinases; KINASE inhibitors; PROTEIN kinases; PROTEIN kinase inhibitors
- Publication
Russian Journal of Organic Chemistry, 2019, Vol 55, Issue 9, p1322
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428019090094