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- Title
Synthesis of tetrahydropyrimidin-2-one derivatives from N-tert-butylurea.
- Authors
Kurbanova, M. M.
- Abstract
The article presents a study which examines a new three-component condensation of ethyl acetoacetate with N-tert-butylurea and aromatic aldehydes. It performs a one-pot synthesis of some pyrimidinone derivatives in the presence of trichloroacetic acid. Results of the condensation lead to the formation of ethyl 3-tert-butyl-6-methyl-2-oxo-4-R-1,2,3,4-tetrahydropyrimidine-5-carboxylates I-III in 70% yield. The general procedure carried out for the synthesis of compounds I-VI is also presented.
- Subjects
ETHYL acetoacetate; ALDEHYDES; PYRIMIDINES; CONDENSATION products (Chemistry); ORGANIC synthesis
- Publication
Russian Journal of Organic Chemistry, 2008, Vol 44, Issue 10, p1562
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428008100321