We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Regional Cerebral Glucose Metabolism in Monozygotic Twins Discordant for Alzheimers Disease.
- Authors
T. Järvenpää; I. Räihä; J. Kaprio; M. Koskenvuo; M. Laine; T. Kurki; T. Vahlberg; T. Viljanen; K. Ahonen; J.O. Rinne
- Abstract
We investigated regional cerebral glucose metabolic rates (rCMRgluc) with positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in 7 monozygotic twin pairs discordant for Alzheimers disease (AD). Ten healthy volunteers with comparable mean age and educational level served as controls. In the hippocampus, the mean ± SD rCMRgluc were 0.20 ± 0.03 μmol/ml/min for the demented twins, 0.21 ± 0.03 μmol/ml/min for their non-demented co-twins, and 0.23 ± 0.02 μmol/ml/min for the controls. The mean hippocampal rCMRgluc was reduced in the demented twins (p = 0.006), compared with the controls. In the lateral temporal cortex, the mean ± SD rCMRgluc were 0.27 ± 0.05, 0.28 ± 0.04, and 0.32 ± 0.02 μmol/ml/min, respectively. These mean rates were reduced both in the demented (p = 0.02) and the non-demented (p = 0.01) twins, compared with the controls. In conclusion, in the demented twins, the reduction of rCMRgluc was detected in the hippocampus and lateral temporal cortex, i.e. the 2 brain areas which show early changes in pathological and imaging studies in AD. Their non-demented co-twins showed milder reductions, which may be an indication of genetic susceptibility for dementia, and an early sign of a dementing illness in them.Copyright © 2003 S. Karger AG, Basel
- Subjects
GLUCOSE; METABOLISM; POSITRON emission tomography; ALZHEIMER'S disease; HIPPOCAMPUS (Brain)
- Publication
Dementia & Geriatric Cognitive Disorders, 2003, Vol 16, Issue 4, p245
- ISSN
1420-8008
- Publication type
Article