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- Title
Bioresorbable scaffolds for percutaneous coronary interventions.
- Authors
Gogas, Bill D.
- Abstract
Innovations in drug-eluting stents (DES) have substantially reduced rates of in-segment restenosis and early stent thrombosis, improving clinical outcomes following percutaneous coronary interventions (PCI). However a fixed metallic implant in a vessel wall with restored patency and residual disease remains a precipitating factor for sustained local inflammation, instent neo-atherosclerosis and impaired vasomotor function increasing the risk for late complications attributed to late or very late stent thrombosis and late target lesion revascularization (TLR) (late catch-up). The quest for optimal coronary stenting continues by further innovations in stent design and by using biocompatible materials other than cobalt chromium, platinum chromium or stainless steel for engineering coronary implants. Bioresorbable scaffolds made of biodegradable polymers or biocorrodible metals with properties of transient vessel scaffolding, local drug-elution and future restoration of vessel anatomy, physiology and local hemodynamics have been recently developed. These devices have been utilized in selected clinical applications so far providing preliminary evidence of safety showing comparable performance with current generation drugeluting stents (DES). Herein we provide a comprehensive overview of the current status of these technologies, we elaborate on the potential benefits of transient coronary scaffolds over permanent stents in the context of vascular restoration therapy, and we further focus on the evolving challenges these devices have to overcome to compete with current generation DES.
- Subjects
TISSUE scaffolds; CORONARY heart disease treatment; CORONARY heart disease prevention; CORONARY restenosis prevention; SURGICAL stents; REVASCULARIZATION (Surgery)
- Publication
Global Cardiology Science & Practice, 2014, Vol 2014, Issue 4, p264
- ISSN
2305-7823
- Publication type
Article
- DOI
10.5339/gcsp.2014.55