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- Title
Ring‐Opening/Cyclization of Cyclobutanone Oxime Esters with Alkenes in Biomass‐Derived Solvent Using Copper Catalyst and Inorganic Oxidant.
- Authors
Zheng, Yan‐Nan; Liu, Yi; Cai, Xue‐Er; Wu, Hong‐Li; Huang, Xun‐Jie; Liu, Yi‐Lin; Wei, Wen‐Ting
- Abstract
A novel method for the ring‐opening/cyclization of cyclobutanone oxime esters with three different types of alkenes for the synthesis of valuable 2‐pyrrolidones and benzimidazo[2,1‐a]isoquinolin‐6(5H)‐ones is demonstrated for the first time, which uses CuCl as a catalyst and K2S2O8 as an oxidant in a biomass‐derived solvent 2‐methyltetrahydrofuran (2‐MeTHF). This protocol is highly efficient and gives full conversions of the substrates with good functional group compatibility. The use of economic and stable copper catalyst along with inorganic oxidant for the ring‐opening/cyclization in green solvent makes it a benign and sustainable strategy.
- Subjects
COPPER catalysts; RING formation (Chemistry); OXIDIZING agents; SOLVENTS; ALKENES; ESTERS
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 6, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202200183