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- Title
A Facile Synthesis of Pyrido[2,3 :3,4]pyrazolo[1,5-a]pyrimidine and Pyrido[2',3':3,4]pyrazolo[5,1-c][1,2,4]triazine Bearing a Thiophene Moiety.
- Authors
Elsaman, Tilal; Fares, Mohamed; Abdel-Aziz, Hatem A.; Attia, Mohamed I.; Ghabbour, Hazem A.; Dawood, Kamal M.
- Abstract
Pyridinone derivative 8 was synthesized and transformed into the respective chloropyridine 9, which was allowed to react with hydrazine hydrate to afford pyrazolo [3,4-b]pyridin-3-amine derivative 11. Compound 11 was used as a key intermediate for a facile synthesis of the title compounds 14,15,17, 21a,b, and 24a-c where the reaction of 11 with some 1,3-dielecrophiles resulted in the formation of pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidines 14,15, and 17, whereas diazotization of compound 11 gave the respective diazonium salt 18 which was coupled with some active methylene-containing compounds to give the corresponding hydrazones 19a,b and 22a-c. Cyclization of the latter hydrazones yielded the pyrido[2',3':3,4]pyrazolo[5,1-c] [1,2,4]triazines 21a,b and 24a-c, respectively.
- Subjects
PYRIMIDINE synthesis; PYRAZOLONES; TRIAZINES; THIOPHENES; MOIETIES (Chemistry); PYRIDONE derivatives
- Publication
Journal of Chemistry, 2013, p1
- ISSN
2090-9063
- Publication type
Article
- DOI
10.1155/2013/463515