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- Title
Assessment of diastolic function of normal fetal heart using dual-gate Doppler.
- Authors
Takano, M.; Nakata, M.; Nagasaki, S.; Ueyama, R.; Morita, M.
- Abstract
<bold>Objectives: </bold>The ratio of mitral peak early diastolic filling to early diastolic mitral annular velocity (E/e') reflects diastolic cardiac function in adults. Dual-gate Doppler (DD) enables measurements of E/e' in the same heart beat. This study was designed to assess the utility of the DD method for measurement of fetal E/e' and determine reference ranges for normal fetuses.<bold>Methods: </bold>This prospective study comprised normal singleton pregnancies undergoing fetal echocardiography between 16 and 36 weeks of gestation. According to the DD method, E-wave velocity on pulsed-wave Doppler and e'-wave on tissue Doppler imaging were measured simultaneously on an apical or basal four-chamber view, and fetal E/e' was calculated. Spearman's correlation coefficient was used to assess the relationship between gestational age (GA) and E-wave and e'-wave velocities and E/e'.<bold>Results: </bold>A total of 133 pregnancies were included in this study and all E/e' measurements were successful. Significant correlation was observed between GA and both left ventricular (LV) E/e' (r s = -0.666, P < 0.001) and right ventricular (RV) E/e' (r s = -0.607, P < 0.001). The regression equations for bilateral E/e' were: LV-E/e' = 17.341 - 0.631GA + 0.008 × GA2 (mean ± SD, R 2 = 0.440 ± 1.333); and RV-E/e' = 19.156 - 0.794GA + 0.012GA2 (R 2 = 0.419 ± 1.329).<bold>Conclusions: </bold>Bilateral E/e' of normal fetuses, measured using the DD method, decreased with GA, which is considered to be related to myocardial maturity. DD is a useful and convenient method for evaluating fetal E/e' in order to assess diastolic function in the prenatal period. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
- Subjects
DIASTOLE (Cardiac cycle); FETAL heart; DOPPLER echocardiography; HEART function tests; FETAL echocardiography; MEASUREMENT of flow velocity; FETAL heart rate; PHYSIOLOGY; BLOOD flow measurement; COMPARATIVE studies; FETAL ultrasonic imaging; GESTATIONAL age; HEMODYNAMICS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; REFERENCE values; RESEARCH; EVALUATION research; FETAL development
- Publication
Ultrasound in Obstetrics & Gynecology, 2018, Vol 52, Issue 2, p238
- ISSN
0960-7692
- Publication type
journal article
- DOI
10.1002/uog.18821