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- Title
Early onset post-transplant lymphoproliferative disease is associated with allograft localization.
- Authors
Bakker, Nicolaas A.; Van Imhoff, Gustaaf W.; Verschuuren, Erik A. M.; van Son, Willem J.; Homan van der Heide, Jaap J.; Veeger, Nic J. G. M.; Kluin, Philip M.; Kluin-Nelemans, Hanneke C.
- Abstract
Bakker NA, van Imhoff GW, Verschuuren EAM, van Son WJ, Homan van der Heide JJ, Veeger NJGM, Kluin PM, Kluin-Nelemans HC. Early onset post-transplant lymphoproliferative disease is associated with allograft localization.Clin Transplant 2005 DOI: 10.1111/j.1399-0012.2005.00342.x© Blackwell Munksgaard, 2005Post-transplant lymphoproliferative disease (PTLD) is a major complication after solid organ transplantation. We analyzed incidence, patient characteristics, clinical presentation, and prognostic factors for treatment outcome and survival of PTLD patients transplanted at our center. Records from adult kidney and lung transplant recipients, transplanted between January 1985 and December 2002 with a histologically confirmed diagnosis of PTLD, were retrieved. Histology was reviewed and prognostic factors for treatment outcome were evaluated by multivariable analysis. Of 1354 kidney and 206 lung transplants, PTLD was diagnosed in 40 transplant recipients (2.6%). Lung transplant recipients had a significantly higher incidence of PTLD (8.3%) than kidney transplant recipients (1.7%). Sites of presentation were highly heterogeneous. Notably, PTLD localized in the allograft occurred significantly earlier after transplantation than PTLD localized outside the allograft (p = 0.001). This was true for lung (p = 0.006) as well as for kidney transplant recipients (p = 0.03). In multivariable Cox regression, performance status (p = 0.01) and advanced stage (p = 0.04) were factors negatively predictive for response to first-line treatment. Only performance status remained as negative predictive factor for survival (p = 0.002) and freedom from tumor progression (p = 0.01). In conclusion, the allograft is significantly more often involved as primary site of PTLD presentation during the first post-transplant year. This may have clinical consequences and give new insights in pathogenesis of PTLD. Performance status and stage are important risk factors for outcome of PTLD.
- Subjects
LYMPHOPROLIFERATIVE disorders; KIDNEY transplantation; LUNG transplantation; HOMOGRAFTS; TRANSPLANTATION of organs, tissues, etc.; PROGNOSIS
- Publication
Clinical Transplantation, 2005, Vol 19, Issue 3, p327
- ISSN
0902-0063
- Publication type
Article
- DOI
10.1111/j.1399-0012.2005.00342.x