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- Title
Association of Campylobacter jejuni Infection With Childhood Guillain-Barré Syndrome: A Case-Control Study.
- Authors
Kalra, Veena; Chaudhry, Rama; Dua, Tarun; Dhawan, Benu; Sahu, Jitendra K.; Mridula, B.
- Abstract
A prospective case-control study was conducted to determine the association between Campylobacter jejuni infection and childhood Guillain-Barré syndrome in the Indian population. We found evidence of recent Campylobacter jejuni infection in 27.7% of patients with Guillain-Barré syndrome, as compared with 2.3% in neurological controls (P =.003) and 2.3% in nonneurological controls (P =.003). Of the 15 patients with Campylobacter jejuni infection, 8 (53.3%) reported having had diarrhea within 12 weeks before the onset of the neurologic illness. Our results suggest association between recent Campylobacter jejuni infection and bulbar weakness (P =.043). No statistical difference was observed between the Campylobacter jejuni positive and negative groups with respect to age, other clinical features, albuminocytological dissociation, and residual paralysis at follow-up. It is concluded that subclinical Campylobacter jejuni infection is an important antecedent illness in childhood Guillain-Barré syndrome in the Indian population.
- Subjects
INDIA; CAMPYLOBACTER infections; CAMPYLOBACTER jejuni; GUILLAIN-Barre syndrome; JUVENILE diseases; DIARRHEA; PARALYSIS; CHILDREN; CASE-control method
- Publication
Journal of Child Neurology, 2009, Vol 24, Issue 6, p664
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073808325649