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- Title
Results of an unrelated transplant search strategy using partially HLA-mismatched cord blood as an immediate alternative to HLA-matched bone marrow.
- Authors
Dalle, J. H.; Duval, M.; Moghrabi, A.; Wagner, E.; Vachon, M. F.; Barrette, S.; Bernstein, M.; Champagne, J.; David, M.; Demers, J.; Rousseau, P.; Winikoff, R.; Champagne, M. A.
- Abstract
Summary:Cord blood (CB) is an alternative to other sources of stem cells for transplantation. However, the impact of including CB in the initial strategy of unrelated graft search in a cohort of patients has been the object of limited analysis. Here, we report the results of such a strategy in 91 consecutive children. Absence of mismatch was required for adult donors, and up to two mismatches were allowed for CB grafts, with a nucleated cell dose over 2.5 × 107 cells/kg. A graft was found for 84 of the 85 children who remained available for a 3-month search. In all, 64 patients were transplanted, 36 with CB and 28 with bone marrow (BM). Primary graft failure, acute grade II-IV and extensive chronic graft-versus-host disease occurred in five, five and zero CB, and in three, one and two BM patients, respectively. The 3-year survival was 59% in CB and 57% in BM patients. Accepting CB as a source of stem cells offers a graft to almost every child in need of an unrelated transplantation, with a probability of survival similar to that of unrelated BM transplantation.Bone Marrow Transplantation (2004) 33, 605-611. doi:10.1038/sj.bmt.1704433 Published online 26 January 2004
- Subjects
HLA histocompatibility antigens; GRAFT versus host disease; BONE marrow; COHORT analysis; STEM cells
- Publication
Bone Marrow Transplantation, 2004, Vol 33, Issue 6, p605
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704433