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- Title
Antibiotic production by Streptomyces hygroscopicus CH-7 in medium containing Schiff base complexes.
- Authors
Ilić, Slavica B.; Konstantinović, Sandra S.; Cvijović, Gordana D. Gojgić; Veljković, Vlada B.
- Abstract
Influence of a modified media on Hexaene H-85 and Azalomycine B production by Streptomyces hygroscopicus CH-7 was investigated. The amino acid L-tryptophan, as a nitrogen source, was replaced with isatin-3-thiosemicarbazone and its complexes with some divalent metal ions. Isatin-3-thiosemicarbazone was synthesized in crude glycerol obtained as a byproduct in biodiesel production from sunflower oil. The complexes were characterized by elemental microanalysis and magnetic susceptibility, as well as, by Atomic absorption(AA), Fourier-transform infrared (FTIR) and Ultraviolet-visible (UV/VIS) spectroscopic methods. The spectral studies indicated an octahedral geometry for the Mn(II), Fe(II) and Ni(II) complexes and a tetrahedral one for the Zn(II) complex. Comparing to the basal medium, isatin-3-thiosemicarbazone (ITC) and its metal complexes in the concentration of 0.5 g dm-3 showed better results in the antibiotics production. Use of medium supplemented with the Fe(II) complex resulted in the maximum Hexaene H-85 and Azalomycine B concentrations of 306 μg cm-3 and 127 μg cm-3, respectively. Addition of ITC and its complexes changed the morphology of S. hygroscopicus CH-7 from filaments to pellets as a dominant shape in media resulting in higher antibiotic production.
- Subjects
SCHIFF bases; STREPTOMYCES; SUNFLOWER seed oil; GLYCERIN; MAGNETIC susceptibility; MASS media use; TRYPTOPHAN
- Publication
Chemical Industry / Hemijska Industrija, 2019, Vol 73, Issue 2, p93
- ISSN
0367-598X
- Publication type
Article
- DOI
10.2298/HEMIND181016008I