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- Title
The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin.
- Authors
Ilić-Stojanović, Snežana S.; Nikolić, Vesna D.; Nikolić, Ljubiša B.; Zdravković, Aleksandar S.; Kapor, Agneš J.; Popsavin, Mirjana M.; Petrović, Slobodan D.
- Abstract
The aim of this work was the preparation of the inclusion complex of naproxen with 2- hydroxypropyl-β-cyclodextrin (HP-β-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-β-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, 1H NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation has started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen:2-hydroxypropyl-β-cyclodextrin was photostable for a period of 30 days.
- Subjects
NAPROXEN; PHOTODEGRADATION; CYCLODEXTRINS
- Publication
Chemical Industry / Hemijska Industrija, 2015, Vol 69, Issue 4, p361
- ISSN
0367-598X
- Publication type
Article
- DOI
10.2298/HEMIND131128050I