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- Title
Comment on: "Preterm Physiologically Based Pharmacokinetic Model, Part I and Part II".
- Authors
Völler, Swantje; Flint, Robert B.; Simons, Sinno H. P.; Knibbe, Catherijne A. J.
- Abstract
The lack of adequate dosing regimens mostly due to off-label use and the high interindividual variability in both pharmacokinetics (PK) and pharmacodynamics (PD) make these infants more prone to suffer from overexposure, adverse effects and treatment failure [[3]]. We therefore highly value the efforts by Abduljalil et al. to get one step closer to being able to predict the PK in preterm neonates; however, we believe this can only be a first stepping stone towards better PK predictions, and some points deserve further attention before the model can be used in practice. Birth leads to complex physiological changes in multiple organ systems, independent from gestational age, including the cardiovascular, respiratory, hepatic and renal systems, all of which impact the maturation of the PK of drugs [[4]-[6]].
- Subjects
PHARMACOKINETICS; DRUG side effects; PREMATURE infants; FETAL growth retardation; BIOAVAILABILITY
- Publication
Clinical Pharmacokinetics, 2021, Vol 60, Issue 5, p677
- ISSN
0312-5963
- Publication type
letter
- DOI
10.1007/s40262-021-00993-4