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- Title
Anti-tumor T cell response and protective immunity in mice that received sublethal irradiation and immune reconstitution.
- Authors
Ma, Jun; Urba, Walter J.; Si, Lüsheng; Wang, Yili; Fox, Bernard A.; Hu, Hong-Ming
- Abstract
To test whether homeostasis-driven T cell proliferation in reconstituted lymphodepleted hosts would improve the therapeutic efficacy of tumor vaccines, normal mice and reconstituted lymphopenic mice (RLM; C57BL/6 mice rendered lymphopenic with sublethal total-body irradiation and reconstituted with naive splenocytes) were used in the vaccination and challenge experiments with weakly immunogenic F10 melanoma cells. Only limited protection was observed in vaccinated normal mice (16.7%), whereas significantly greater protection was induced in vaccinated RLM (63.2%). Protective immunity in RLM depended on CD8 T cells. Following vaccination, a significant increase in the percentage of CD44
- Publication
European Journal of Immunology, 2003, Vol 33, Issue 8, p2123
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200324034