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- Title
Alginate–Chitosan Hydrogel Formulations Sustain Baculovirus Delivery and VEGFA Expression Which Promotes Angiogenesis for Wound Dressing Applications.
- Authors
Schaly, Sabrina; Islam, Paromita; Abosalha, Ahmed; Boyajian, Jacqueline L.; Shum-Tim, Dominique; Prakash, Satya
- Abstract
Hydrogel wound dressings are effective in their ability to provide a wound-healing environment but are limited by their ability to promote later stages of revascularization. Here, a biosafe recombinant baculovirus expressing VEGFA tagged with EGFP is encapsulated in chitosan-coated alginate hydrogels using ionic cross-linking. The VEGFA, delivered by the baculovirus, significantly improves cell migration and angiogenesis to assist with the wound-healing process and revascularization. Moreover, the hydrogels have an encapsulation efficiency of 99.9%, no cytotoxicity, antimicrobial properties, good blood compatibility, promote hemostasis, and enable sustained delivery of baculoviruses over eight days. These hydrogels sustain baculovirus delivery and may have clinical implications in wound dressings or future gene therapy applications.
- Subjects
WOUND healing; NEOVASCULARIZATION; HYDROCOLLOID surgical dressings; HYDROGELS; GENE therapy; BACULOVIRUSES
- Publication
Pharmaceuticals (14248247), 2022, Vol 15, Issue 11, p1382
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph15111382