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- Title
Synthesis of new 2- and 3-hydroxyquinoline-4-carboxylic acid derivatives as potential antioxidants.
- Authors
Massoud, Mohammed A.; El Bialy, Serry A.; Bayoumi, Waleed A.; El Husseiny, Walaa M.
- Abstract
A new series of 3-aryl-2-hydroxyquinoline-4-carboxylic acids 17a,b, 2-aryl-3-hydroxyquinoline-4-carboxylic acids 12a-d and their derivatives 13-16 and 18-21 were designed, synthesized and evaluated for their antioxidant activity using the ABTS assay method. Compounds 14 and 21a,b showed good antioxidant activity, whereas the remaining compounds displayed mild to moderate activity. All compounds were characterized by physical and spectral data.
- Subjects
HYDROXYQUINOLINE; BENZIMIDAZOLES; AROMATIC compound synthesis; CARBOXYLIC acids; CHEMICAL synthesis; ANTIOXIDANT analysis; DRUG synthesis
- Publication
Heterocyclic Communications, 2014, Vol 20, Issue 2, p81
- ISSN
0793-0283
- Publication type
Article
- DOI
10.1515/hc-2013-0163