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- Title
Report of the ISTH registry on pregnancy and COVID-19-associated coagulopathy (COV-PREG-COAG).
- Authors
Kazi, Sajida; Othman, Maha; Khoury, Rasha; Bernstein, Peter S; Thachil, Jecko; Ciantar, Etienne; Ferrara, Laura; Netto, Manju; Abdul-Kadir, Rezan; Malinowski, A Kinga
- Abstract
Background: Concerns about COVID-19-associated coagulopathy (CAC) in pregnant individuals were raised in early pandemic. Methods: An ISTH-sponsored COVID-19 coagulopathy in pregnancy (COV-PREG-COAG) international registry was developed to describe incidence of coagulopathy, VTE, and anticoagulation in this group. Results: All pregnant patients with COVID-19 from participating centers were entered, providing 430 pregnancies for the first pandemic wave. Isolated abnormal coagulation parameters were seen in 20%; more often with moderate/severe disease than asymptomatic/mild disease (49% vs 15%; p < 0.0001). No one met the ISTH criteria for disseminated intravascular coagulopathy (DIC), though 5/21 (24%) met the pregnancy DIC score. There was no difference in antepartum hemorrhage (APH) with asymptomatic/mild disease versus moderate/severe disease (3.4% vs 7.7%; p = 0.135). More individuals with moderate/severe disease experienced postpartum hemorrhage (PPH) (22.4% vs 9.3%; p = 0.006). There were no arterial thrombotic events. Only one COVID-associated venous thromboembolism (VTE) was reported. Conclusions: Low rates of coagulopathy, bleeding, and thrombosis were observed among pregnant people in the first pandemic wave.
- Subjects
HEMORRHAGE complications; PREGNANCY; BLOOD coagulation disorders; VEINS; QUESTIONNAIRES; FISHER exact test; INTERNATIONAL agencies; SEVERITY of illness index; DESCRIPTIVE statistics; POSTPARTUM hemorrhage; CHI-squared test; PREGNANCY outcomes; CONTENT mining; THROMBOEMBOLISM; COVID-19
- Publication
Obstetric Medicine (1753-495X), 2024, Vol 17, Issue 1, p13
- ISSN
1753-495X
- Publication type
Article
- DOI
10.1177/1753495X231206931