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- Title
Functional Effects of let-7g Expression in Colon Cancer Metastasis.
- Authors
Chang, Che-Mai; Wong, Henry Sung-Ching; Huang, Chien-Yu; Hsu, Wen-Li; Maio, Zhi-Feng; Chiu, Siou-Jin; Tsai, Yao-Ting; Chen, Ben-Kuen; Wan, Yu-Jui Yvonne; Wang, Jaw-Yuan; Chang, Wei-Chiao
- Abstract
MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the let-7 family has been identified as a tumor suppressor in different types of cancers. However, the function of the let-7 family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of let-7g in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of let-7g. In addition, in vitro as well as in vivo studies have been performed to uncover the effects of let-7g on CRC. We found that the expression of let-7g was significantly lower in CRC specimens. Our results further supported the inhibitory effects of let-7g on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for let-7g in the pathogenesis of CRC and suggest let-7g as a potential therapeutic target for CRC treatment.
- Subjects
CHINA; ANIMAL experimentation; CELL physiology; COLON tumors; GENE expression; GENOMES; METASTASIS; MICE; RNA
- Publication
Cancers, 2019, Vol 11, Issue 4, p489
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers11040489