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- Title
FOXK2 Transcription Factor and Its Emerging Roles in Cancer.
- Authors
Nestal de Moraes, Gabriela; Carneiro, Luciana da Torre; Maia, Raquel Ciuvalschi; Lam, Eric Wing-Fai; Sharrocks, Andrew David
- Abstract
Forkhead box (FOX) transcription factors compose a large family of regulators of key biological processes within a cell. FOXK2 is a member of FOX family, whose biological functions remain relatively unexplored, despite its description in the early nineties. More recently, growing evidence has been pointing towards a role of FOXK2 in cancer, which is likely to be context-dependent and tumour-specific. Here, we provide an overview of important aspects concerning the mechanisms of regulation of FOXK2 expression and function, as well as its complex interactions at the chromatin level, which orchestrate how it differentially regulates the expression of gene targets in pathophysiology. Particularly, we explore the emerging functions of FOXK2 as a regulator of a broad range of cancer features, such as cell proliferation and survival, DNA damage, metabolism, migration, invasion and metastasis. Finally, we discuss the prognostic value of assessing FOXK2 expression in cancer patients and how it can be potentially targeted for future anticancer interventions.
- Subjects
TUMOR prognosis; CELL proliferation; CANCER invasiveness; CELL motility; CHROMOSOMES; DNA; GENE expression; METASTASIS; SURVIVAL; TRANSCRIPTION factors; TUMORS; SYMPTOMS; CELL survival
- Publication
Cancers, 2019, Vol 11, Issue 3, p393
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers11030393