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- Title
Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review.
- Authors
Kennedy, Deborah A.; Cooley, Kieran; Skidmore, Becky; Fritz, Heidi; Campbell, Tara; Seely, Dugald
- Abstract
Vitamin D has reported anti-cancer and anti-inflammatory properties modulated through gene transcription and non-genomic signaling cascades. The purpose of this review was to summarize the available research on interactions and pharmacokinetics between vitamin D and the pharmaceutical drugs used in patients with cancer. Hypercalcemia was the most frequently reported side effect that occurred in high dose calcitriol. The half-life of 25(OH)D3 and/or 1,25(OH)2D3 was found to be impacted by cimetidine; rosuvastatin; prednisone and possibly some chemotherapy drugs. No unusual adverse effects in cancer patients; beyond what is expected from high dose 1,25(OH)2D3 supplementation, were revealed through this review. While sufficient evidence is lacking, supplementation with 1,25(OH)2D3 during chemotherapy appears to have a low risk of interaction. Further interactions with vitamin D3 have not been studied.
- Subjects
THERAPEUTIC use of vitamin D; CANCER chemotherapy; COMBINATION drug therapy; DIETARY supplements; INFORMATION storage &; retrieval systems; MEDICAL databases; MEDLINE; PATIENT safety; PHARMACOKINETICS; SYSTEMATIC reviews; CHOLECALCIFEROL; CALCITRIOL
- Publication
Cancers, 2013, Vol 5, Issue 1, p255
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers5010255