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- Title
Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells.
- Authors
Mukherjee, Sulagna; Choi, Minji; Yun, Jong Won
- Abstract
Recently, adaptive non-shivering thermogenesis has attracted considerable attention because it can elevate energy expenditure and help treat obesity. Despite the numerous reports related to UCP1-driven thermogenesis, little is known regarding UCP1-independent thermogenesis in adipose tissues and muscle. Therefore, it is essential to identify the molecular targets for UCP1-independent thermogenesis and their mechanisms to increase the energy expenditure pharmacologically in both adipocytes and muscle. This study examined whether trans-anethole (TA), a major component of the essential oils of fennel, induces UCP1-independent SERCA/SLN-based thermogenesis and promotes the lipid metabolism in muscle cells. TA enhanced myogenesis, lipolysis, and the oxidative metabolism in C2C12 muscle cells. More importantly, TA activated the SERCA/SLN/RYR axis, thereby inducing thermogenesis in muscle cells. Molecular docking analysis revealed a good interaction between SERCA with TA with a strong bind activity. In conclusion, the current data unveiled a previously unknown mechanism of TA in myoblasts and suggests a possible therapeutic agent in muscles by enhancing energy expenditure.
- Subjects
MUSCLE cells; BODY temperature regulation; ADIPOSE tissues; MYOBLASTS; MUSCLE metabolism; ESSENTIAL oils; FAT cells
- Publication
Biotechnology & Bioprocess Engineering, 2022, Vol 27, Issue 6, p938
- ISSN
1226-8372
- Publication type
Article
- DOI
10.1007/s12257-022-0242-2