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- Title
High throughput screening methods for ω-transaminases.
- Authors
Mathew, Sam; Shin, Giyoung; Shon, Minsu; Yun, Hyungdon
- Abstract
Recently, ω-transaminases have been increasingly used to synthesize amine compounds by reductive amination of prochiral ketones which are of high pharmacological significance. However, the conventional methods for evaluating these enzymes are time consuming and have often been regarded as a bottle neck in developing these enzymes as industrial biocatalysts. In the past few years, several high throughput screening methods have been developed for fast evaluation and identification of ω-transaminase. This review summarizes the various methodologies developed for rapidly screening ω-transaminases.
- Subjects
HIGH throughput screening (Drug development); AMINOTRANSFERASES; AMINE synthesis; AMINATION; LITERATURE reviews
- Publication
Biotechnology & Bioprocess Engineering, 2013, Vol 18, Issue 1, p1
- ISSN
1226-8372
- Publication type
Article
- DOI
10.1007/s12257-012-0544-x