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- Title
Nitrosonium-Mediated Phenol-Arene Cross-Coupling Involving Direct C-H Activation.
- Authors
Eisenhofer, Anna; Wille, Uta; König, Burkhard
- Abstract
The nitrosonium ion (NO+) is a highly versatile nitration and nitrosation reagent, as well as a strong one-electron oxidant. Herein, we describe an environmentally benign and mild method for the in situ formation of NO+ from readily available inorganic nitrate salts, i.e. lithium nitrate, through a finely tuned interplay between formic acid and MeOH, which are used as the solvent system. This methodology was applied to the NO+-induced oxidative C-H activation of methoxysubstituted phenols, which are versatile lignin-derived aromatic feedstocks, to achieve C-C cross-coupling reactions with arenes. The regeneration of NO+ by atmospheric molecular oxygen enables substoichiometric use of the nitrate.
- Subjects
NITROSATION; METAL ions; COUPLING reactions (Chemistry)
- Publication
Australian Journal of Chemistry, 2017, Vol 70, Issue 4, p407
- ISSN
0004-9425
- Publication type
Article
- DOI
10.1071/CH16622