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- Title
Synthesis and Characterization of all Possible Diastereoisomers of Alvimopan.
- Authors
REDDY, BEERAVALLI RAMALINGA; DUBEY, MANOJ KUMAR; REDDY, CH. VENKATA RAMANA; BANDICHHOR, RAKESHWAR
- Abstract
Isolation of all possible diastereomers of alvimopan 1 was found to be challenging. In order to perform cut off studies during analytical method development, it was mandatory to synthesize and characterize all the diastereomeric impurities. Here in, our efforts toward the synthesis and isolation of alvimopan (1) diastereomers are discussed.
- Subjects
DIASTEREOISOMERS synthesis; ALVIMOPAN; NATURAL products; HYDRATES; CHIRAL centers
- Publication
Oriental Journal of Chemistry, 2018, Vol 34, Issue 2, p963
- ISSN
0970-020X
- Publication type
Article
- DOI
10.13005/ojc/340246