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- Title
Highlight: The Surprising Endurance of DNA's Smallest Repeats.
- Authors
McGrath, Casey
- Abstract
Microsatellites, short repeating sequences of DNA, are commonly found in the genomes of various organisms. They are used to study inheritance, genetic diversity, and population dynamics. Despite their variability among individuals, a new study reveals that microsatellites have remained remarkably stable over vast evolutionary time. The study used ancient and modern Adélie penguin genomes to compare microsatellite dynamics and found that microsatellite length tends to remain stable over thousands and even millions of years. This suggests a dynamic equilibrium in the replication process that generates length polymorphism. The study also highlights the potential functional role of microsatellites in genome architecture and phenotypic diversity.
- Subjects
HUNTINGTIN protein; DNA; MICROSATELLITE repeats; GENETIC drift; GENETIC variation; HUNTINGTON disease; NON-coding DNA
- Publication
Genome Biology & Evolution, 2024, Vol 16, Issue 3, p1
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evae044