We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
LINEs Contribute to the Origins ofMiddle Bodies of SINEs besides 3' Tails.
- Authors
Kojima, Kenji K.
- Abstract
Short interspersed elements (SINEs), which are nonautonomous transposable elements, require the transposition machinery of long interspersed elements (LINEs) to mobilize. SINEs are composed of two or more independently originating parts. The 5' region is called the "head" and is derived mainly from small RNAs, and the 3' region ("tail") originates from the 30 region of LINEs and is responsible for being recognized by counterpart LINE proteins. The origin of the middle "body" of SINEs is enigmatic, although significant sequence similarities among SINEs from very diverse species have been observed. Here, a systematic analysis of the similarities among SINEs and LINEs deposited on Repbase, a comprehensive database of eukaryotic repeat sequences was performed. Three primary findings are described: 1) The 5' regions of only two clades of LINEs, RTE and Vingi, were revealed to have contributed to the middle parts of SINEs; 2) The linkage of the 5' and 3' parts of LINEs can be lost due to occasional tail exchange of SINEs; and 3) The previously proposedCeph-domain was revealed to be a fusion of aCORE-domain and a 5' part of RTE clade of LINE. Basedon these findings, a hypothesis that the 5' parts of bipartite nonautonomous LINEs, which possess only the 5' and 3' regions of the original LINEs, can contribute to the undefined middle part of SINEs is proposed.
- Subjects
NON-coding RNA; CHROMOSOMAL translocation; EUKARYOTES; RIBOSOMAL RNA; NUCLEOTIDE sequencing
- Publication
Genome Biology & Evolution, 2018, Vol 10, Issue 1, p370
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evy008