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- Title
P232 - LEVELS OF HOMOCYSTEINE, VITAMIN B12 AND FOLIC ACID IN PATIENTS WITH SUBCLINICAL AND CLINICAL HYPOTHYROIDISM.
- Authors
İLASLAN, Erkam; KAHRAMAN, Ahmet; DEMIR, Serap; KÖKEN, Tülay
- Abstract
Thyroid hormones have an important role on growth and skeletal development. Hypothyroidism is characterized by decreased metabolism resulting from insufficient production or ineffectiveness of thyroid hormones. The relationship between hypothyroidism and homocysteine which is a cardiovascular risk factor attract attention but, various results have been taken in a lot of studies. Homocysteine, vitamin B12 and folate metabolism is interrelated. The aim of our study is to investigate the relationship between both subclinical and clinical hypothyroidism and homocysteine, vitamin B12 and folat levels. In this study, blood samples which were taken from 20 adult patients with clinical hypothyroidism and 14 adult patients with subclinical hypothyroidism who were diagnosed for the first time samples were analyzed. The control group was 17 healthy subjects. If TSH level of patients are higher than 4,20 µlU/mL, but the free T3 (fT3) levels are lower than 1.80 pg/mL and free T4 (fT4) levels are lower than 0.89 ng/dL, they were accepted as the patients with clinical hypothyroidism. If TSH level of patients are higher than 4,20 µlU/mL, but the free T3 (fT3) and free T4 (fT4) levels are normal, they were accepted as the patients with subclinical hypothyroidism. As a result, homocysteine, vitamin B12 and folate levels in both subclinical and clinical hypothyroidism group were not different than the control group statistically, in spite of a slight decrease was noted.
- Subjects
HOMOCYSTEINE; SULFUR amino acids; VITAMIN B12; CORRINOIDS; HYPOTHYROIDISM
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2012, Vol 37, Issue S1, p373
- ISSN
0250-4685
- Publication type
Article