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- Title
Polymorphisms of Dioxin Receptor Complex Components and Detoxification-Related Genes Jointly Confer Susceptibility to Advanced-Stage Endometriosis in the Taiwanese Han Population.
- Authors
Wu, Cheng-Hsuan; Guo, Chao-Yu; Yang, Jyuer-Ger; Tsai, Horng-Der; Chang, Yu-Jun; Tsai, Pei-Chien; Hsu, Chao-Chin; Kuo, Pao-Lin
- Abstract
Citation Wu C-H, Guo C-Y, Yang J-G, Tsai H-D, Chang Y-J, Tsai P-C, Hsu C-C, Kuo P-L. Polymorphisms of dioxin receptor complex components and detoxification-related genes jointly confer susceptibility to advanced-stage endometriosis in the Taiwanese Han population. Am J Reprod Immunol 2012; 67: 160-168 Problem To establish a multilocus model for studying the effect of dioxin receptor complex components and detoxification-related enzymes on advanced endometriosis. Method of study Six single-nucleotide polymorphisms (SNPs) and two deletion polymorphisms from eight genes (CYP1A1, CYP1B1, GSTM1, GSTT1, GSTP1, AhR, ARNT, and AhRR) were genotyped. Results In the single SNP analysis, GSTM1 null type and AhRR variant type were associated with a significantly increased risk of endometriosis [odds ratio (OR) = 2.38 and 2.45, respectively]. Using multiple SNPs in the logistic regression for covariates, wild-type AhR and mutant AhRR combination was significantly higher in patients (67.8%) than in controls (48.0%) (OR = 2.76). On the other hand, mutant AhRR in combination with GSTM1 null genotype was significantly higher in patients (35.5%) than in controls (19.3%) (OR = 6.12). Conclusion Polymorphisms of dioxin receptor complex components and detoxification-related genes jointly confer susceptibility to advanced-stage endometriosis in the Taiwanese Han population.
- Subjects
DIOXINS; ENDOMETRIOSIS; GENETIC research; GENETIC polymorphism research; SINGLE nucleotide polymorphisms
- Publication
American Journal of Reproductive Immunology, 2012, Vol 67, Issue 2, p160
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/j.1600-0897.2011.01077.x