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- Title
The Influence of Dexmedetomidine as an Adjuvant in Intrathecal Labor Analgesia: A Multicenter Study on Efficacy and Maternal Satisfaction.
- Authors
Lao, Chengyi; Zhu, Maoling; Yang, Yu; Lin, Xuejiang; Huang, Ruiping; Wei, Xiaofen; Wei, Xiaoyu
- Abstract
In this study, we examined the impact of dexmedetomidine (DEX) on the effectiveness of epidural analgesia and labor outcomes. We administered different doses of DEX combined with 0.1% ropivacaine for epidural analgesia to evaluate the clinical effects and safety. To assess the effects of different concentrations of DEX in parturient women receiving epidural analgesia, we conducted a randomized double‐blind trial. We selected 400 parturient women and randomly assigned them to 4 groups, with 100 parturient women in each group: S0.1 (0.1 µg/mL DEX), S0.2 (0.2 µg/mL DEX), S0.3 (0.3 µg/mL DEX), and a control group (0.3 µg/mL sufentanil). Post‐analgesia, we recorded the Bromage score, duration of labor, method of delivery, bleeding, neonatal Apgar score, adverse reactions, and maternal satisfaction. The number of patients with a Bromage score of ≥2 and the incidence of bradycardia were higher in the S0.3 group compared with the other 3 groups (P <.05), whereas the high satisfaction rate was lower in the S0.3 group (P <.05). Moreover, we found that the number of times that additional patient‐controlled analgesia was administered was higher in the S0.1 group compared with the remaining 3 groups (P <.05). The control group exhibited a higher incidence of pruritus than the other 3 groups (P <.05). In conclusion, when administering spinal anesthesia for the relief of labor pain, epidural analgesia with 0.1% ropivacaine combined with 0.2 µg/mL DEX provides relatively ideal analgesic effects, higher maternal satisfaction, and reduces the incidence of pruritus, compared with the combination of 0.1% ropivacaine and 0.3 µg/mL sufentanil.
- Subjects
RESEARCH; ROPIVACAINE; LABOR pain (Obstetrics); ANESTHESIA adjuvants; EPIDURAL anesthesia; OBSTETRICAL analgesia; SATISFACTION; SUFENTANIL; IMIDAZOLES; PREGNANCY outcomes; RANDOMIZED controlled trials; PATIENT-controlled analgesia; COMPARATIVE studies; BLIND experiment; ITCHING; RESEARCH funding; DESCRIPTIVE statistics; STATISTICAL sampling; APGAR score
- Publication
Journal of Clinical Pharmacology, 2024, Vol 64, Issue 1, p111
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1002/jcph.2335