We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Direct Access to Unique C‐5'‐Acyl Modified Nucleosides through Liebeskind–Srogl Cross‐Coupling Reaction.
- Authors
Maverick, Mary Anne; Gaillard, Marie; Vasseur, Jean‐Jacques; Debart, Françoise; Smietana, Michael
- Abstract
The chemical functionalization at C‐5' position of nucleosides has been significantly less studied compared to the C‐1', C‐2' and C‐3' sugar positions in spite of its potential important role for biological activity. We describe here the synthesis of new carbothioate nucleosides which were then engaged in a Liebeskind‐Srogl reaction with various boronic acids for the preparation of diversely modified C‐5'‐acyl nucleosides. Applied to pyrimidine nucleosides in the DNA and RNA series, the reaction showed a broad substrate scope and more than 25 examples were synthesized in good‐to‐excellent isolated yields. This general and efficient Pd‐catalyzed and Cu(I)‐mediated cross‐coupling represents a convenient method to prepare a diverse set of 5'‐modified nucleosides and paves the way for further transformation into a variety of potentially bioactive compounds via the possible conversion of the C‐5'‐ketone.
- Subjects
NUCLEOSIDES; PYRIMIDINE nucleosides; BORONIC acids; BIOACTIVE compounds; DNA
- Publication
European Journal of Organic Chemistry, 2022, Vol 2022, Issue 21, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202101061