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- Title
β-LACTAM ANALOGS OF OXETANOCINS - SYNTHESIS AND BIOLOGICAL ACTIVITY.
- Authors
GŁOWACKA, IWONA E.; GRABKOWSKA-DRUŻYC, MAGDALENA; LEBELT, LIWIA; ANDREI, GRACIELA; SCHOLS, DOMINIQUE; SNOECK, ROBERT; PIOTROWSKA, DOROTA G.
- Abstract
Kinugasa reaction of the N-substituted-C-(diethoxyphosphonyl)nitrones with selected N-propargylated nucleobases produced mixtures of diastereoisomeric 3-substituted-(4-diethoxyphosphonyl)azetidin-2-ones. Several obtained compounds out of all 84 newly obtained compounds showed moderate activity toward VZV. Among them, azetidin-2-ones cis-8n and trans-8w exhibited the highest inhibitory activities toward TK-VZV strain with EC50 values of 13.37 and 10.51 μM, respectively.
- Subjects
LACTAMS; NITRONES; PHOSPHONATES; ANTIVIRAL agents; BASE pairs
- Publication
Acta Poloniae Pharmaceutica, 2022, Vol 79, Issue 2, p167
- ISSN
0001-6837
- Publication type
Article
- DOI
10.32383/appdr/149323