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- Title
Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles.
- Authors
Haseley, Leah A.; Wisnieski, Jeffrey J.; Denburg, Michelle R.; Michael-Grossman, Abigail R.; Ginzler, Ellen M.; Gourley, Mark F.; Hoffman, Jean H.; Kimberly, Robert P.; Salmon, Jane E.
- Abstract
Antibodies to Clq in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles. Autoantibodies to the coliagen-like region of the first complement component (ClqAB) are found in patients with systemic lupus erythematosus (SLE), particularly those with renal disease. In a cohort of 46 SLH patients with diffuse proliferative glomerulonephritis, we found declining ClqAB titers in 77% of treatment responders and in only 38% of treatment non-responders (<em>P</em> < 0.03). To further characterize this autoantibody, we tested 240 SLE patients for the presence of ClqAB, Positive titers were found in 44% of patients with renal disease and 18% of patients without renal disease (χ² <em>P</em>0.0003). Analysis of IgG subclass revealed IgG2 ClqAB alone in 34%, igGl ClqAB alone in 20%, and both igGl and IgG2 in 46% of patients. Fewer than 10% of patients had measurable titers of IgG3 or IgG4 ClqAB. The pathogenic role of these IgG2-skewed ClqAB may relate to impaired immune complex clearance by the mononuclear phagocyte system; IgG2 antibodies are efficiently recognized by only one IgG receptor, the H131 allele of FcγRIIa (FcγRIIa-H131). In contrast, FcγRIIa-R131, which is characterized by minimal IgG2 binding, has recently been associated with lupus nephritis. In our ClqAB positive patients, the presence of FcγRIIAR131 was associated with an increased risk for renal disease. Autoantibodies to Clq may have pathogenic significance in SLE patients with genetic defects in the ability to dear IgG2 containing immune complexes.
- Subjects
SYSTEMIC lupus erythematosus; COLLAGEN diseases; AUTOIMMUNE diseases; IMMUNOGLOBULINS; IMMUNOGLOBULIN G; KIDNEY diseases
- Publication
Kidney International, 1997, Vol 52, Issue 5, p1375
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1997.464