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- Title
Distal urinary acidification from Homer Smith to the present.
- Authors
Gluck, Stephen L.; Iyori, Masahiro; Holliday, L. Shannon; Kostrominova, Tatiana; Lee, Beth S.; Gluck, S L; Iyori, M; Holliday, L S; Kostrominova, T; Lee, B S
- Abstract
Since Smith's time, the essential role of collecting duct intercalated cells in controlling net acid excretion has been recognized. Rather than employing an H(+)-exchange mechanism, intercalated cells have V-ATPase on the plasma membrane and in plasmalemma-associated tubulovesicles, which functions in the bicarbonate reabsorption, regeneration, and bicarbonate secretion required for acid-base homeostasis. Several distinct mechanisms participate in regulating V-ATPase-driven H+ secretion in different cell types: (1) Renal epithelial cells have the capacity to express different structural forms of V-ATPase that have intrinsic differences in their enzymatic properties. 2) The kidney produces cytosolic regulatory proteins, capable of interacting directly with the V-ATPase, that may modify its activity. V-ATPases in different cell types may differ in the degree to which their activity is affected by regulatory factors, as a result of variations in V-ATPase structure. (3) In the alpha intercalated cell, the number of active V-ATPases on the luminal membrane is controlled in vivo by membrane vesicle-mediated traffic that may require unidentified mediators. In the beta intercalated cell, the number of active V-ATPases on the basolateral membrane may be controlled by regulated assembly and disassembly, responding directly to extracellular pH.
- Subjects
URINE; ACIDIFICATION; EXCRETION; CELL membranes; BIOLOGICAL transport; SMITH, Homer William, 1895-1962; KIDNEY physiology; ACIDS; ANIMAL experimentation; COMPARATIVE studies; HISTORY; KIDNEY tubules; KIDNEYS; RESEARCH methodology; MEDICAL cooperation; NEPHROLOGY; PHYSIOLOGY; RESEARCH; EVALUATION research
- Publication
Kidney International, 1996, Vol 49, Issue 6, p1660
- ISSN
0085-2538
- Publication type
journal article
- DOI
10.1038/ki.1996.242