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- Title
Physiologic studies in normal and uremic sheep: I. The experimental model.
- Authors
Eschbach, Joseph W.; Adamson, John W.; Dennis, Melvin B.
- Abstract
A model of chronic renal failure was created in nine adult sheep by two-stage, subtotal nephrectomy. Carotidjugular cannulas provided clot-free access for 72 to 274 days without exit-site infections. All sheep became uremic and anemic. Median survival, while uremic. was 145 days (72 to 327 days), although three were sacrificed. Five required dialysis within the first week of uremia, and median survival on dialysis was 70 days (41 to 177 days). Sheep that maintained adequate nutrition survived the longest on dialysis. Mean creatinine and BUN levels in the stable uremic and dialyzed sheep were 4.8/95 and 7.8/59 mg/dl. respectively. The other serum chemistries remained unchanged (mean values) from normal, although one sheep died of hypercalcemia(17.8 mg/dl). Renal blood flow correlated to GFR in both normal and uremic states. GFR fell more than serum creatinine rose, suggesting extrarenal excretion of creatinine.
- Subjects
CHRONIC kidney failure; SHEEP as laboratory animals; UREMIA; ANEMIA; CREATININE
- Publication
Kidney International, 1980, Vol 18, Issue 6, p725
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1980.191