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- Title
Hexokinase: a novel sugar kinase coupled to renal epithelial cell survival.
- Authors
Robey, R. Brooks
- Abstract
Hexokinases have emerged as novel mediators of the antiapoptotic effects of growth factors in a wide variety of cells. These effects have been attributed to highly regulated direct physical and functional interactions with mitochondria. The demonstration that mitochondrial hexokinases can prevent apoptogenic 'Bax attack' in proximal tubule cells suggests a need to reexamine the specific contributions of hexokinases and glucose metabolism in this nephron segment and elsewhere within the kidney.
- Subjects
GLUCOKINASE; MITOCHONDRIAL pathology; GLUCOSE; KIDNEY tubules; EPITHELIAL cells; MITOCHONDRIA
- Publication
Kidney International, 2011, Vol 79, Issue 11, p1163
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2011.20